HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dihydrofuran-2-yl)-2-fluoropyridine → 2-Fluoro-3-(tetrahydrofuran-2-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dihydrofuran-2-yl)-2-fluoropyridine | HCID 67167650 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Fluoro-3-(tetrahydrofuran-2-yl)pyridine | HCID 67168066 | 88.5% |
Reaction Steps
A round-bottom flask containing 3-(2,5-dihydrofuran-2-yl)-2-fluoropyridine (170 mg, 1 mmol) and 10% Pd/C in methanol (3.1 mL) is evacuated under vacuum and filled with hydrogen with the aid of a balloon. The reaction is stirred overnight at room temperature and filtered over celite. The solvent is evaporated in vacuo to give 148 mg of 2-fluoro-3-(tetrahydrofuran-2-yl)pyridine. MS (m/z): 168 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232289B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-c7f34726c7cc4286a571c2928920ef14 |
| Source note | uspto-grants-2012_07 |