HCID 52951552, compound → HCID 67168341, compound

HRID 1517613Notes

Reaction equation

HRID 1517613 reaction equation
[F:1][C:2]1[S:6][C:5]2[C:7]3([O:13][CH2:14][CH2:15][C:4]=2[CH:3]=1)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]3.[CH:16]([C:18]1[C:19]([CH3:31])=[N:20][N:21]([C:23]2[C:28]([C:29]#[N:30])=[CH:27][CH:26]=[CH:25][N:24]=2)[CH:22]=1)=O>>[F:1][C:2]1[S:6][C:5]2[C:7]3([O:13][CH2:14][CH2:15][C:4]=2[CH:3]=1)[CH2:12][CH2:11][N:10]([CH2:16][C:18]1[C:19]([CH3:31])=[N:20][N:21]([C:23]2[C:28]([C:29]#[N:30])=[CH:27][CH:26]=[CH:25][N:24]=2)[CH:22]=1)[CH2:9][CH2:8]3

Participants

3

Reactant 2

HCID 52951552HCID 52951552, compoundHCID 58268556HCID 58268556, compound

Product 1

HCID 67168341HCID 67168341, compoundYield 32%

Procedure

This compound is essentially prepared as described in Preparation 7 by using 2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine] and 2-(4-formyl-3-methyl-pyrazol-1-yl)pyridine-3-carbonitrile. The residue is purified by SCX to give 2-[4-[(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine]-1′-yl)methyl]-3-methyl-pyrazol-1-yl]pyridine-3-carbonitrile in a 32% yield. MS (m/z): 424 (M+1).

Workup

  1. customThis compound is essentially prepared
  2. customas described in Preparation 7
  3. customThe residue is purified by SCX

Sources & evidence

ORD record
ord-1ffbe4e4491f4298a158d22a96cfe2a9
Source dataset
uspto-grants-2012_07
Patent number
US08232289B2

Reaction notes

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