反应详情

温度

130 °C

A mixture of 2-chloro-4,4-difluoro-1′-[(3-methyl-1H-pyrazol-4-yl)methyl]spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (0.20 g, 0.53 mmol), 4-[(2-bromo-3-pyridyl)methyl]morpholin-3-one (0.21 g, 0.77 mmol), copper(I) iodide (0.015 g, 0.078 mmol) and cesium carbonate (0.36 g, 1.10 mmol) in dimethylformamide (5 mL) is degassed by bubbling argon for 15 minutes. (1R,2R)—N,N′-dimethylcyclohexane-1,2-diamine (0.02 g, 0.14 mmol) is added while degassing for 15 minutes and then the mixture is heated to 130° C. for 16 hours. After completion, the reaction mixture is allowed to cool to room temperature and filtered through celite. The residue is washed with ethyl acetate (2×25 mL) and the filtrate is washed with water (30 mL). The aqueous layer was extracted with ethyl acetate (2×25 mL) and the combined organic extracts are dried over sodium sulfate and concentrated in vacuo. The crude mixture is purified by column chromatography over silica gel eluting with dichloromethane/methanol (96:4) to yield 0.09 g (30%) of the title compound. MS (m/z): 564 (M+1).

1. customis degassed
2. customby bubbling argon for 15 minutes
3. customwhile degassing for 15 minutes
4. temperatureto cool to room temperature
5. filtrationfiltered through celite
6. washThe residue is washed with ethyl acetate (2×25 mL)
7. washthe filtrate is washed with water (30 mL)
8. extractionThe aqueous layer was extracted with ethyl acetate (2×25 mL)
9. dry with materialthe combined organic extracts are dried over sodium sulfate
10. concentrationconcentrated in vacuo
11. customThe crude mixture is purified by column chromatography over silica gel eluting with dichloromethane/methanol (96:4)