Trifluoroacetic acid → HCID 86605020, compound

HRID 1517651Notes

Reaction equation

HRID 1517651 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]([N:5]1[CH2:10][CH2:9][CH:8]([NH:11][NH:12]C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)=[O:4].[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[F:21][C:2]([F:1])([F:20])[C:3]([N:5]1[CH2:10][CH2:9][CH:8]([NH:11][NH2:12])[CH2:7][CH2:6]1)=[O:4].[F:22][C:23]([F:28])([F:27])[C:24]([O-:26])=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86605021HCID 86605021, compound

Product 1

HCID 86605020HCID 86605020, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.0 g (16.1 mmol) tert-butyl N′-[1-(2,2,2-trifluoro-acetyl)-piperidin-4-yl]-hydrazine-carboxylate are dissolved in 50 ml dichloromethane and combined with 6.0 ml (77.9 mmol) trifluoroacetic acid. The reaction mixture is stirred for 5 hours at ambient temperature, then concentrated by evaporation. Yield: 6.70 g

Workup

  1. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-efe3247449b2408ab25f0fd532c5457e
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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