HCID 178420350, compound → HCID 178511576, compound

HRID 1517657Notes

Reaction equation

HRID 1517657 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[C:21]1([N:18]2[CH2:17][CH2:16][N:15]([C@H:12]3[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH2:20][CH2:19]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 178420350HCID 178420350, compound

Product 1

HCID 178511576HCID 178511576, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

270 mg (0.61 mmol) trans-dibenzyl-[4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-amine are dissolved in 5 ml of methanol and hydrogenated on 40 mg Pd/C (10%) at 20-30° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and conc. HCl. Yield: 110 mg. The cis-isomer may be prepared analogously.

Workup

  1. customthe residue is crystallised from ethanol and conc. HCl
  2. customThe cis-isomer may be prepared analogously

Sources & evidence

ORD record
ord-a43fb1db312f48019b68b94d8559dbf2
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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