HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178420350, compound → HCID 178511576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178420350 | HCID 178420350 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178511576 | HCID 178511576 | — |
Reaction Steps
270 mg (0.61 mmol) trans-dibenzyl-[4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-amine are dissolved in 5 ml of methanol and hydrogenated on 40 mg Pd/C (10%) at 20-30° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and conc. HCl. Yield: 110 mg. The cis-isomer may be prepared analogously.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232286B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-a43fb1db312f48019b68b94d8559dbf2 |
| Source note | uspto-grants-2012_07 |