Methanol → HCID 178511578, compound

HRID 1517658Notes

Reaction equation

HRID 1517658 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@@H:12]([N:15]2[CH2:20][CH2:19][N:18]([CH:21]3[CH2:23][CH2:22]3)[CH2:17][CH:16]2C)[CH2:11][CH2:10]1)C1C=CC=CC=1.[CH3:32]O>[Pd]>[CH:23]1([CH2:21][N:18]2[CH2:17][CH2:16][N:15]([C@@H:12]3[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH2:20][CH2:19]2)[CH2:22][CH2:32]1

Participants

4

Reactant 2

HCID 887MethanolHCID 178429835HCID 178429835, compound

Product 1

HCID 178511578HCID 178511578, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

8.5 g (20 mmol) cis-dibenzyl-[4-(4-cyclopropyl methyl-piperazin-1-yl)-cyclohexyl]-amine are dissolved in 170 ml of methanol and hydrogenated on 1.7 g Pd/C (10%) at 30-50° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and conc. HCl. Yield: 4.4 g

Workup

  1. customthe residue is crystallised from ethanol and conc. HCl

Sources & evidence

ORD record
ord-1e0774b1c59742c296eaf46a5c6639bf
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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