Hydrochloric Acid → HCID 58641570, compound

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Reaction Steps

650 ml 37% hydrochloric acid are placed in 650 ml of water and 99 g (0.27 mol) N-(1-phenyl-4,5-dihydro-1H-pyrazolo[3′,4′:3,4]benzo[1,2-d]thiazol-7-yl)-acetamide (prepared analogously to Example 1) are dissolved therein. The solution is refluxed for 2 hours with stirring. After cooling to ambient temperature the mixture is carefully made basic (pH 10-11) with sodium hydroxide solution. The precipitate formed is suction filtered and stirred out with methanol. Yield: 66 g (m.p.: 307-308° C.)

Provenance & Evidence