Hydrochloric Acid → HCID 58641570, compound

HRID 1517664Notes

Reaction equation

HRID 1517664 reaction equation
Cl.[C:2]1([N:8]2[C:12]3[C:13]4[S:17][C:16]([NH:18]C(=O)C)=[N:15][C:14]=4[CH2:22][CH2:23][C:11]=3[CH:10]=[N:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>O>[C:2]1([N:8]2[C:12]3[C:13]4[S:17][C:16]([NH2:18])=[N:15][C:14]=4[CH2:22][CH2:23][C:11]=3[CH:10]=[N:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59006510HCID 59006510, compound

Product 1

HCID 58641570HCID 58641570, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

650 ml 37% hydrochloric acid are placed in 650 ml of water and 99 g (0.27 mol) N-(1-phenyl-4,5-dihydro-1H-pyrazolo[3′,4′:3,4]benzo[1,2-d]thiazol-7-yl)-acetamide (prepared analogously to Example 1) are dissolved therein. The solution is refluxed for 2 hours with stirring. After cooling to ambient temperature the mixture is carefully made basic (pH 10-11) with sodium hydroxide solution. The precipitate formed is suction filtered and stirred out with methanol. Yield: 66 g (m.p.: 307-308° C.)

Workup

  1. dissolutionare dissolved
  2. temperatureThe solution is refluxed for 2 hours
  3. customThe precipitate formed
  4. filtrationfiltered
  5. stirringstirred out with methanol

Sources & evidence

ORD record
ord-06d8135fb8d140ea814440eff2e75ac8
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

Loading…