Dichloromethane → HCID 57741249, compound

HRID 1517665Notes

Reaction equation

HRID 1517665 reaction equation
C(NC([NH:8][CH2:9][C:10]#[C:11][CH2:12][NH:13][C:14]([NH:16][C:17]1[S:18][C:19]2[C:25]3[N:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[N:27]=[CH:28][C:24]=3[CH2:23][CH2:22][C:20]=2[N:21]=1)=[O:15])=O)(C)(C)C.ClCCl>FC(F)(F)C(O)=O>[NH2:8][CH2:9][C:10]#[C:11][CH2:12][NH:13][C:14]([NH:16][C:17]1[S:18][C:19]2[C:25]3[N:26]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[N:27]=[CH:28][C:24]=3[CH2:23][CH2:22][C:20]=2[N:21]=1)=[O:15]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 57741276HCID 57741276, compound

Product 1

HCID 57741249HCID 57741249, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

0.1 g (0.2 mmol) of the compound obtained in Example 11 are suspended in 0.5 ml trifluoroacetic acid and 2 ml dichloromethane and stirred overnight at ambient temperature. The reaction mixture is evaporated down, the residue taken up in acetone and the product is precipitated by the addition of ethereal hydrochloric acid.

Workup

  1. customThe reaction mixture is evaporated down
  2. customthe product is precipitated by the addition of ethereal hydrochloric acid

Sources & evidence

ORD record
ord-1562e20a501545baabe4d2e1638bfeb5
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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