反应详情

0.3 g (1.1 mmol) of the compound obtained in Example 71 are suspended in 15 ml dichloromethane, combined with 0.4 ml (2.5 mmol) triethylamine and gently refluxed. 0.2 ml (2.3 mmol) propionic acid chloride are added and the mixture is refluxed for 5 hours with stirring. After cooling to ambient temperature the reaction solution is washed with sodium hydrogen carbonate and water, dried and evaporated to dryness. The residue is stirred with diethyl ether and suction filtered. Yield: 0.2 g (m.p.: 274-275° C.)

1. temperaturegently refluxed
2. temperaturethe mixture is refluxed for 5 hours
3. washis washed with sodium hydrogen carbonate and water
4. customdried
5. customevaporated to dryness
6. stirringThe residue is stirred with diethyl ether and suction
7. filtrationfiltered