HCID 57741263, compound → HCID 11637989, compound

HRID 1517671Notes

Reaction equation

HRID 1517671 reaction equation
[C:1]([NH:4][C:5]1[S:6][C:7]2[C:16]3[N:15]=[C:14]([N:17]([CH2:25][C:26]#[CH:27])C(=O)OC(C)(C)C)[N:13]=[CH:12][C:11]=3[CH2:10][CH2:9][C:8]=2[N:28]=1)(=[O:3])[CH3:2]>Cl>[CH2:25]([NH:17][C:14]1[N:13]=[CH:12][C:11]2[CH2:10][CH2:9][C:8]3[N:28]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[S:6][C:7]=3[C:16]=2[N:15]=1)[C:26]#[CH:27]

Participants

3

Reactant 1

HCID 57741263HCID 57741263, compound

Product 1

HCID 11637989HCID 11637989, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.05 g (0.13 mmol) of the compound obtained in Example 82 are dissolved in 5 ml ethereal hydrochloric acid and stirred for 16 hours at ambient temperature. The resulting solid is suction filtered, triturated with diethyl ether/acetone 9:1 and suction filtered again. Yield: 0.03 g

Workup

  1. filtrationfiltered
  2. customtriturated with diethyl ether/acetone 9:1 and suction
  3. filtrationfiltered again

Sources & evidence

ORD record
ord-9e68b2b94a3a47b8b8f6e9da5070254b
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

Loading…