HCID 67203573, compound → HCID 67203482, compound

HRID 1517696Notes

Reaction equation

HRID 1517696 reaction equation
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[CH:12]=[C:13]([CH3:17])[CH:14]=[CH:15][CH:16]=2)[CH2:9][N:8]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:7]1)=[O:5])C>Cl>[CH2:18]([N:8]1[CH2:9][CH:10]([C:11]2[CH:12]=[C:13]([CH3:17])[CH:14]=[CH:15][CH:16]=2)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 1

HCID 67203573HCID 67203573, compound

Product 1

HCID 67203482HCID 67203482, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

1-Benzyl-4-m-tolyl-pyrrolidine-3-carboxylic acid ethyl ester (4.6 g, 14.5 mmol) was suspended in aqueous HCl (73 mL, 18.0 M), and stirred overnight at 80° C. The reaction mixture was concentrated via rotary evaporation and placed on the vacuum line. MS calculated for C19H21NO2+H: 296, observed: 296.

Workup

  1. concentrationThe reaction mixture was concentrated via rotary evaporation

Sources & evidence

ORD record
ord-6933d7d40b544a249be1e39321fb3c8c
Source dataset
uspto-grants-2012_07
Patent number
US08232311B2

Reaction notes

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