Trifluoroacetic acid → HCID 66646394, compound

HRID 1517795Notes

Reaction equation

HRID 1517795 reaction equation
C(OC(=O)/C=C/C1([S:14]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][N:24]([CH2:36][CH2:37][O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:25][CH2:26][C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[NH:29][CH:28]=3)=[CH:19][CH:18]=2)(=[O:16])=[O:15])C=CNC1)(C)(C)C.[C:47]([OH:53])([C:49](F)(F)F)=[O:48]>ClCCl>[C:42]([Si:39]([CH3:40])([CH3:41])[O:38][CH2:37][CH2:36][N:24]([CH2:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:29]2[CH:30]=[CH:35][C:27](/[CH:26]=[CH:49]/[C:47]([OH:53])=[O:48])=[CH:28]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1)[CH2:25][CH2:26][C:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[NH:29][CH:28]=1)([CH3:44])([CH3:43])[CH3:45]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66646170HCID 66646170, compound2×

Product 1

HCID 66646394HCID 66646394, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(E)-3-{3-[4-({[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-indol-3-yl)-ethyl]-amino}methyl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylic acid tert-butyl ester (compound D5) is dissolved in dichloromethane (50 ml). Then it is added TFA and the mixture is stirred for 26 hours. After evaporation, the residue is washed with toluene.

Workup

  1. customAfter evaporation
  2. washthe residue is washed with toluene

Sources & evidence

ORD record
ord-9834e50595a14733b0f3f76cc4c04ba3
Source dataset
uspto-grants-2012_07
Patent number
US08232297B2

Reaction notes

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