Succinic Acid → HCID 66669792, compound

HRID 1517843Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21]([C:23]4[C:24](=[O:44])[N:25]([C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)[N:26]([CH2:29][C@H:30]([O:32][C:33](=[O:37])[CH2:34][NH:35][CH3:36])[CH3:31])[C:27]=4[CH3:28])=[O:22])=[CH:16][C:15]=3[F:45])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.[C:46]([OH:53])(=[O:52])[CH2:47][CH2:48][C:49]([OH:51])=[O:50]>>[C:46]([OH:53])(=[O:52])[CH2:47][CH2:48][C:49]([OH:51])=[O:50].[CH3:36][NH:35][CH2:34][C:33]([O:32][C@H:30]([CH3:31])[CH2:29][N:26]1[C:27]([CH3:28])=[C:23]([C:21](=[O:22])[NH:20][C:17]2[CH:18]=[CH:19][C:14]([O:13][C:7]3[C:6]4[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[N:10]=[CH:9][CH:8]=3)=[C:15]([F:45])[CH:16]=2)[C:24](=[O:44])[N:25]1[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)=[O:37]

Participants

Reactant 2

HCID 1110Succinic Acid

HCID 46937772(R)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl 2-(methylamino)acetate

Product 1

HCID 66669792HCID 66669792, compound

Procedure

The title compound was prepared according to the procedure described in Example 39 step 3 by using (R)-1-(4-(4-(7-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl-2-(methylamino)acetate (82.3 mg, 0.134 mmol) and succinic acid (31.6 mg, 0.268 mmol, Guangdong Chemical Reagent Engineering-technological Research and Development Center). The title compound was abtained as a pale yellow solid (70.5 mg, 72%).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-38c50877f35a4f22bb12fcd7f7965378
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232294B2

Reaction notes

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