Oxalic acid dihydrate → HCID 46938116, compound

HRID 1517857Notes

Reaction equation

HRID 1517857 reaction equation
[CH3:1][NH:2][CH2:3][C:4]([O:6][C@H:7]([CH3:44])[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([C:15](=[O:36])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][N:18]=2)[C:11](=[O:37])[N:10]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:5].O.O.[C:47]([OH:52])(=[O:51])[C:48]([OH:50])=[O:49]>>[C:47]([OH:52])(=[O:51])[C:48]([OH:50])=[O:49].[CH3:1][NH:2][CH2:3][C:4]([O:6][C@H:7]([CH3:44])[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([C:15](=[O:36])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][N:18]=2)[C:11](=[O:37])[N:10]1[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)=[O:5]

Participants

3

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 46938058HCID 46938058, compound

Product 1

HCID 46938116HCID 46938116, compound

Procedure

The title compound was prepared according to the procedure described in Example 59 Step 3 by using (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl-carbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (100 mg, 0.168 mmol) and oxalic acid dihydrate (63.5 mg, 0.50 mmol). The title compound was obtained as a yellow solid (71.5 mg, 62%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-91832b2368c54e3e88209467f2e559cf
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

Loading…