p-Toluenesulfonic acid → HCID 86645604, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 59 Step 3 by using p-toluene sulphonic acid (76.6 mg, 0.40 mmol, Shanghai chemical reagent procurement and supply of five joint chemical factory) and (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-ylcarbamoyl)-2,3-dihydro-5-meth-yl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (100 mg, 0.168 mmol). The title compound was obtained as a yellow solid (86.8 mg, 66.4%).

Provenance & Evidence