p-Toluenesulfonic acid → HCID 86645604, compound

HRID 1517860Notes

Reaction equation

HRID 1517860 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][NH:13][CH2:14][C:15]([O:17][C@H:18]([CH3:55])[CH2:19][N:20]1[C:24]([CH3:25])=[C:23]([C:26](=[O:47])[NH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][C:35]3[C:44]4[C:39](=[CH:40][C:41]([O:45][CH3:46])=[CH:42][CH:43]=4)[N:38]=[CH:37][CH:36]=3)=[CH:30][N:29]=2)[C:22](=[O:48])[N:21]1[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)=[O:16]>>[CH3:11][C:1]1[CH:2]=[CH:3][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:5][CH:6]=1.[CH3:12][NH:13][CH2:14][C:15]([O:17][C@H:18]([CH3:55])[CH2:19][N:20]1[C:24]([CH3:25])=[C:23]([C:26](=[O:47])[NH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][C:35]3[C:44]4[C:39](=[CH:40][C:41]([O:45][CH3:46])=[CH:42][CH:43]=4)[N:38]=[CH:37][CH:36]=3)=[CH:30][N:29]=2)[C:22](=[O:48])[N:21]1[C:49]1[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=1)=[O:16]

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 46938058HCID 46938058, compound

Product 1

HCID 86645604HCID 86645604, compound

Procedure

The title compound was prepared according to the procedure described in Example 59 Step 3 by using p-toluene sulphonic acid (76.6 mg, 0.40 mmol, Shanghai chemical reagent procurement and supply of five joint chemical factory) and (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-ylcarbamoyl)-2,3-dihydro-5-meth-yl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (100 mg, 0.168 mmol). The title compound was obtained as a yellow solid (86.8 mg, 66.4%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-91a8811cddec49aaadb473e30f5ada5c
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

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