関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Propanoic acid, 3-hydroxy-, phenylmethyl ester | HCID 84459 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | benzyl 3-(tetrahydro-2H-pyran-2-yloxy)propanoate | HCID 66669830 | 88.3% |
反応手順
To a mixture of benzyl 3-hydroxypropanoate (2.041 g, 11.34 mmol) and DHP (1.428 g, 17.01 mmol, Alfa) in 30 mL of dichloromethane was added PPTS (0.283 g, 1.13 mmol, Aldrich) slowly. After stirring at 40° C. for 3 days, the reaction mixture was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE: EtOAc=20:1) to afford the title compound as pale yellow oil (2.64 g, 88.3%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08232294B2 |
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| 出典データセット | uspto-grants-2012_07 |
|---|
| ORD ID | ord-3a49f357bda14a7aa160ce7ffa5caf9d |
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| 出典メモ | uspto-grants-2012_07 |
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