反应详情

温度

40 °C

To a mixture of benzyl 3-hydroxypropanoate (2.041 g, 11.34 mmol) and DHP (1.428 g, 17.01 mmol, Alfa) in 30 mL of dichloromethane was added PPTS (0.283 g, 1.13 mmol, Aldrich) slowly. After stirring at 40° C. for 3 days, the reaction mixture was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE: EtOAc=20:1) to afford the title compound as pale yellow oil (2.64 g, 88.3%).

1. concentrationthe reaction mixture was concentrated in vacuo
2. customthe residue was purified by a silica gel column chromatography (PE: EtOAc=20:1)