反应详情

温度

-10 °C

A mixture of 1-(2-hydroxyethyl)cyclopropanol (310 mg, 3.04 mmol) and triethylamine (614.1 mg, 6.08 mmol) in 10 mL of dichloromethane was stirred at −10° C. for 30 min. Methanesulfonyl chloride (348 mg, 3.04 mmol) was added via a syringe. After stirring at −10° C. for 1 hr, the reaction mixture was quenched with ice-water (2 mL) and extracted with dichloromethane (20 mL×4). The combined organic phases were dried over Na2SO4 and concentrated in vacuo to give yellow oil (used for the next step quickly).

1. stirringAfter stirring at −10° C. for 1 hr
2. customthe reaction mixture was quenched with ice-water (2 mL)
3. extractionextracted with dichloromethane (20 mL×4)
4. dry with materialThe combined organic phases were dried over Na2SO4
5. concentrationconcentrated in vacuo
6. customto give yellow oil (