Triethylamine → HCID 86640796, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3-hydroxypropyl)cyclopropanol (140 mg, 1.2 mmol) and triethylamine (0.3 mL, 2.1 mmol) in 8 mL of dichloromethane was stirred at 0° C. for 10 min. Methane-sulfonyl chloride (180 mg, 1.6 mmol) was then added to the mixture via a syringe. After stirring at 0° C. for 1 hr, the mixture was quenched with 2 mL of ice-water and extracted with dichloromethane (10 mL×3). The combined organic phases were dried over Na2SO4 and concentrated in vacuo to give 3-(1-hydroxycyclo-propyl)propyl methanesulfonate as yellow oil (used for the next step immediately).

Provenance & Evidence