反应详情

温度

0 °C

A mixture of 1-(3-hydroxypropyl)cyclopropanol (140 mg, 1.2 mmol) and triethylamine (0.3 mL, 2.1 mmol) in 8 mL of dichloromethane was stirred at 0° C. for 10 min. Methane-sulfonyl chloride (180 mg, 1.6 mmol) was then added to the mixture via a syringe. After stirring at 0° C. for 1 hr, the mixture was quenched with 2 mL of ice-water and extracted with dichloromethane (10 mL×3). The combined organic phases were dried over Na2SO4 and concentrated in vacuo to give 3-(1-hydroxycyclo-propyl)propyl methanesulfonate as yellow oil (used for the next step immediately).

1. stirringAfter stirring at 0° C. for 1 hr
2. customthe mixture was quenched with 2 mL of ice-water
3. extractionextracted with dichloromethane (10 mL×3)
4. dry with materialThe combined organic phases were dried over Na2SO4
5. concentrationconcentrated in vacuo