反应详情

To a mixture of 1-((tetrahydro-2H-pyran-2-yloxy)methyl)cyclopropyl acetate (149 mg, 0.696 mmol) in 10 mL of methanol was added PPTS (18 mg, 0.07 mmol, Aldrich) in portions. After stirring for 5 hrs at rt, the mixture was quenched with 10 mL of water and extracted with dichloromethane (20 mL×3). The combined organic phases were dried over Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE: EtOAc=10:1) to give the title compound as pale yellow oil (46 mg, 35.5%).

1. customthe mixture was quenched with 10 mL of water
2. extractionextracted with dichloromethane (20 mL×3)
3. dry with materialThe combined organic phases were dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customThe residue was purified by a silica gel column chromatography (PE: EtOAc=10:1)