Hydrochloric Acid → 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl 2-aminoacetate hydrochloride

Participants

Reaction Steps

The compound 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl 2-(tert-butoxycarbonylamino)acetate (80 mg, 0.112 mmol) was dissolved in ethyl acetate (8 mL). 2 mL of HCl in ethyl acetate (0.93 mol/L) was added dropwise and the reaction was stirred at rt for 30 minute. The solid was collected by filtration and washed with ethyl acetate (10 mL×2) to afford the title compound as a white solid (11 mg, 15%).

Provenance & Evidence