HRID1517878

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC5(OC(=O)CNC(=O)OC(C)(C)C)CC5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C

HCID66693852

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC5(OC(=O)CN)CC5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C.Cl

HCID66693795

未命名化合物

收率 15%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

The compound 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl 2-(tert-butoxycarbonylamino)acetate (80 mg, 0.112 mmol) was dissolved in ethyl acetate (8 mL). 2 mL of HCl in ethyl acetate (0.93 mol/L) was added dropwise and the reaction was stirred at rt for 30 minute. The solid was collected by filtration and washed with ethyl acetate (10 mL×2) to afford the title compound as a white solid (11 mg, 15%).

WORKUP

后处理

filtrationThe solid was collected by filtration
washwashed with ethyl acetate (10 mL×2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3909fe6518884925aa554011ac272e26
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08232294B2
来源说明: uspto-grants-2012_07

反应 SMILES

C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][O:17][C:18]2[CH:27]=[C:26]3[C:21]([C:22]([O:28][C:29]4[CH:34]=[CH:33][C:32]([NH:35][C:36]([C:38]5[C:39](=[O:51])[N:40]([C:45]6[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=6)[N:41]([CH3:44])[C:42]=5[CH3:43])=[O:37])=[CH:31][C:30]=4[F:52])=[CH:23][CH:24]=[N:25]3)=[CH:20][CH:19]=2)[CH2:15][CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:53]>C(OCC)(=O)C>[ClH:53].[NH2:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][O:17][C:18]2[CH:27]=[C:26]3[C:21]([C:22]([O:28][C:29]4[CH:34]=[CH:33][C:32]([NH:35][C:36]([C:38]5[C:39](=[O:51])[N:40]([C:45]6[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=6)[N:41]([CH3:44])[C:42]=5[CH3:43])=[O:37])=[CH:31][C:30]=4[F:52])=[CH:23][CH:24]=[N:25]3)=[CH:20][CH:19]=2)[CH2:14][CH2:15]1)=[O:11]