反应详情

To a mixture of 1-((tetrahydro-2H-pyran-2-yloxy)methyl)cyclopropyl benzoate (2 g, 7.2 mmol) in 30 mL of MeOH was added PPTS (2.7 g, 10.8 mmol, Aldrich) at rt. The reaction mixture was stirred at rt overnight, then concentrated and purified by a silica gel column chromatography (4:1 (v/v) petroleum ether/EtOAc) to afford the title compound as colorless oil (1.2 g, 87%).

1. concentrationconcentrated
2. custompurified by a silica gel column chromatography (4:1 (v/v) petroleum ether/EtOAc)