反应详情

To a mixture of 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)cyclopropyl benzoate (690 mg, 2.38 mmol) in 20 mL of MeOH was added PPTS (896 mg, 3.57 mmol, Aldrich) at rt. The reaction mixture was stirred at rt overnight, then concentrated and purified by a silica gel column chromatography (4:1 (v/v) petroleum ether/EtOAc) to the title compound as light yellow oil (320 mg, 65%).

1. concentrationconcentrated
2. custompurified by a silica gel column chromatography (4:1 (v/v) petroleum ether/EtOAc) to the title compound as light yellow oil (320 mg, 65%)