HCID 57205387, compound → HCID 59334868, compound

HRID 1517942Notes

Reaction equation

HRID 1517942 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([NH2:12])=[O:11])=[CH:8][S:7][C:6]=2[CH:13]=1.NC1C=CC2SC=C(C(N)=O)C=2C=1.[Cl:27][C:28]1[CH:29]=[C:30]([S:35](NC2C=CC3SC=C(C(N)=O)C=3C=2)(=[O:37])=[O:36])[CH:31]=[C:32]([Cl:34])[CH:33]=1>C(OCC)(=O)C>[Cl:34][C:32]1[CH:31]=[C:30]([S:35]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[C:9]([C:10]([NH2:12])=[O:11])=[CH:8][S:7][C:6]=3[CH:13]=2)(=[O:36])=[O:37])[CH:29]=[C:28]([Cl:27])[CH:33]=1

Participants

5

Reactant 3

HCID 57205387HCID 57205387, compoundHCID 59334919HCID 59334919, compoundHCID 59335015HCID 59335015, compound

Product 1

HCID 59334868HCID 59334868, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Obtained from the reaction of a mixture of 6-amino-benzo[b]thiophene-3-carboxylic acid-amide and 5-amino-benzo[b]thiophene-3-carboxylic acid-amide (Example XII (30)). The crude product is dissolved in hot ethyl acetate. After cooling to ambient temperature the precipitated solid (5-(3,5-dichloro-phenylsulphonylamino)-benzo[b]thiophene-3-carboxylic acid-amide) is filtered off. The mother liquor is freed from the solvents in vacuo and the residue is chromatographed on silica gel, to obtain 6-(3,5-dichloro-phenylsulphonylamino)-benzo[b]thiophene-3-carboxylic acid-amide.

Workup

  1. filtrationis filtered off
  2. customthe residue is chromatographed on silica gel

Sources & evidence

ORD record
ord-8b8610cb7bc3442e94182c610b1e58db
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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