5-Nitro-benzo[b]thiophene-3-carboxylic acid → 5-Nitro-3-benzothiophencarboxylic acid amide

HRID 1517952Notes

Reaction equation

HRID 1517952 reaction equation
[N+:1](C1C=CC2C(C(O)=O)=CSC=2C=1)([O-])=O.[N+:16]([C:19]1[CH:30]=[CH:29][C:22]2[S:23][CH:24]=[C:25]([C:26](O)=[O:27])[C:21]=2[CH:20]=1)([O-:18])=[O:17]>>[N+:16]([C:19]1[CH:30]=[CH:29][C:22]2[S:23][CH:24]=[C:25]([C:26]([NH2:1])=[O:27])[C:21]=2[CH:20]=1)([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 235048365-Nitro-benzo[b]thiophene-3-carboxylic acidHCID 593351106-Nitro-benzo[b]thiophene-3-carboxylic acid

Product 1

HCID 570915765-Nitro-3-benzothiophencarboxylic acid amide

Procedure

are obtained as a mixture during the reaction of a mixture of 6-nitro-benzo[b]-thiophene-3-carboxylic acid and 5-nitro-benzo[b]thiophene-3-carboxylic acid (Example XLV). The crude product is chromatographed on silica gel, while the two products are obtained as a mixture and further reacted directly in Example XII (30).

Workup

  1. customThe crude product is chromatographed on silica gel, while the two products
  2. customare obtained as a mixture

Sources & evidence

ORD record
ord-eeebebb11f37485ab533471d5c34c788
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

Loading…