Ammonia → HCID 59334923, compound

HRID 1517966Notes

Reaction equation

HRID 1517966 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:21]=[C:20]3[C:16]([C:17]([C:23](=[O:27])[C:24](Cl)=[O:25])=[CH:18][N:19]3[CH3:22])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH3:28]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:21]=[C:20]3[C:16]([C:17]([C:23](=[O:27])[C:24]([NH2:28])=[O:25])=[CH:18][N:19]3[CH3:22])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 59335088HCID 59335088, compound

Product 1

HCID 59334923HCID 59334923, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

400 mg [6-(3,5-dichloro-phenylsulphonylamino)-1-methyl-1H-indol-3-yl]-oxo-acetyl-chloride are dissolved in 1.5 ml tetrahydrofuran, combined with 550 μl concentrated ammonia (32% solution in water) and stirred for 3.5 hours. The solvent is eliminated in vacuo and the residue is extracted from a little methanol. The solid is suction filtered and dried in vacuo.

Workup

  1. extractionthe residue is extracted from a little methanol
  2. filtrationfiltered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-bd850c318910441f88afa55aa51b5173
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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