Oxalyl chloride → HCID 59335088, compound

HRID 1517967Notes

Reaction equation

HRID 1517967 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:21]=[C:20]3[C:16]([CH:17]=[CH:18][N:19]3[CH3:22])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:23](Cl)(=[O:27])[C:24]([Cl:26])=[O:25]>C(OCC)C>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:21]=[C:20]3[C:16]([C:17]([C:23](=[O:27])[C:24]([Cl:26])=[O:25])=[CH:18][N:19]3[CH3:22])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 59335073HCID 59335073, compound

Product 1

HCID 59335088HCID 59335088, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

1.1 g 3,5-dichloro-N-(1-methyl-1H-indol-6-yl)phenylsulphonamide are dissolved in 15 ml diethyl ether, cooled to 0° C. and combined with 296 μl oxalyl chloride. Then the mixture is stirred for 2 hours at 0° C. and for 12 hours at ambient temp. The solvents are distilled off at 50° C. The crude product thus obtained is further reacted directly (XLVII).

Workup

  1. distillationThe solvents are distilled off at 50° C

Sources & evidence

ORD record
ord-49cc4559ef834fba98db2846bddee74f
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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