Trifluoroacetic acid → HCID 24936158, compound

HRID 1517972Notes

Reaction equation

HRID 1517972 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18]([C:22](=[O:30])[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][CH2:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:31][C:32]([OH:34])=[O:33])[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18]([C:22](=[O:30])[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][CH2:16]3)(=[O:10])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59335056HCID 59335056, compound

Product 1

HCID 24936158HCID 24936158, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.24 g tert.butyl [(3,5-dichloro-phenylsulphonyl)-(1-phenylcarbamoyl-2,3-dihydro-1H-indol-5-yl)-amino]-acetate are dissolved in 10 ml dichloromethane. 5 ml of trifluoroacetic acid is added with stirring. The mixture is stirred for 2 hours at ambient temperature and then the solvents are eliminated in vacuo. The residue is extracted from diisopropylether and cyclohexane.

Workup

  1. stirringThe mixture is stirred for 2 hours at ambient temperature
  2. extractionThe residue is extracted from diisopropylether and cyclohexane

Sources & evidence

ORD record
ord-a78e1a9b494048e69bdbd9eefe005bc7
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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