HCID 59335131, compound → HCID 59335055, compound

HRID 1517975Notes

Reaction equation

HRID 1517975 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])[C:13]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:14]=2[CH2:15][CH2:16][N:17]3[C:22](=[O:25])[NH:23][CH3:24])(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>Cl.O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:26][C:27]([OH:29])=[O:28])[C:13]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:14]=2[CH2:15][CH2:16][N:17]3[C:22](=[O:25])[NH:23][CH3:24])(=[O:10])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 1

HCID 59335131HCID 59335131, compound

Product 1

HCID 59335055HCID 59335055, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

300 mg tert.butyl [(3,5-dichloro-phenylsulphonyl)-(1-methylcarbamoyl-2,3-dihydro-1H-indol-4-yl)-amino]-acetate are dissolved in 4 ml of a 4 N solution of HCl in dioxane. The mixture is stirred overnight at RT and the solvents are then eliminated in vacuo. The residue is extracted from dichloromethane.

Workup

  1. extractionThe residue is extracted from dichloromethane

Sources & evidence

ORD record
ord-9ebb7729ceb34dad8cdaedc1a6551d6f
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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