Potassium Carbonate → HCID 59335099, compound

HRID 1517978Notes

Reaction equation

HRID 1517978 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:14]([N:17]([CH2:33][C:34]([OH:36])=[O:35])[C:18]2[CH:19]=[CH:20][C:21]3[N:22]([CH2:31][CH3:32])[C:23]4[C:28]([C:29]=3[CH:30]=2)=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:16])=[O:15])[CH:5]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>CO.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([S:14]([N:17]([CH2:33][C:34]([OH:36])=[O:35])[C:18]2[CH:19]=[CH:20][C:21]3[N:22]([CH2:31][CH3:32])[C:23]4[C:28]([C:29]=3[CH:30]=2)=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:16])=[O:15])[CH:5]=[C:6]([C:8]#[CH:9])[CH:7]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 59335128HCID 59335128, compound

Product 1

HCID 59335099HCID 59335099, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

134 mg [(3-chloro-5-trimethylsilylethynyl-phenylsulphonyl)-(9-ethyl-9H-carbazol-3-yl)-amino]-acetic acid are dissolved in 2 ml of methanol, combined with 50 mg potassium carbonate and stirred for 2 hours at ambient temperature. Then the mixture is diluted with dichloromethane and washed with 4 M hydrochloric acid. The organic phase is dried on magnesium sulphate and the solvent is then eliminated in vacuo. The residue is chromatographed on silica gel (dichloromethane/methanol 100:0 to 95:5).

Workup

  1. washwashed with 4 M hydrochloric acid
  2. customThe organic phase is dried on magnesium sulphate
  3. customThe residue is chromatographed on silica gel (dichloromethane/methanol 100:0 to 95:5)

Sources & evidence

ORD record
ord-fb63f46835224888920ede0fe3f4e5ef
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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