HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → HCID 68983741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| Reactant | (5-Chlorothiophen-2-yl)(4-nitrophenyl)methanone | HCID 24723380 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68983741 | HCID 68983741 | — |
Reaction Steps
If one were to take 2 grams (12 mMole) of commercially available (5-chloro-thiophen-2-yl)-(4-nitro-phenyl)-methanone 1 (Reike Metals, Lincoln, Nebr.) and heat it under anhydrous conditions with an excess of ethylene glycol and catalytic amounts of toluene sulfonic acid in toluene, one would obtain the protected 2-(4-nitro-phenyl)-2-thiophen-2-yl-[1,3]dioxolane (2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232402B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-5feba32fe603467089a85049d0d22aad |
| Source note | uspto-grants-2012_07 |