反应详情

The title compound was prepared from 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid (283 mg, 1.55 mmol, as prepared in Example 1, step B) and 4-bromobenzene-1,2-diamine (1.3 eq., 377 mg, 2.02 mmol) in 68% overall yield (299 mg) according to the procedures described in Example 1, steps F and G. 1H-NMR (400 MHz, d4-MeOH) δ: 7.74 (s, 1H), 7.51 (d, J=8.6 Hz, 1H), 7.40 (dd, J=8.6, 1.8 Hz, 1H), 3.25 (s, 2H), 1.69-1.88 (m, 6H), 1.43-1.63 (m, 4H).

1. customoverall yield (299 mg)