4-Bromobenzene-1,2-diamine → HCID 178419324, compound

HRID 1518158Notes

Reaction equation

HRID 1518158 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[O:10]1[C:14]2([CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:13][C:12]([C:20](O)=O)=[N:11]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][C:20]([C:12]3[CH2:13][C:14]4([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]4)[O:10][N:11]=3)=[N:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 3235934-Bromobenzene-1,2-diamineHCID 509941141-Oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid

Product 1

HCID 178419324HCID 178419324, compound

Procedure

The title compound was prepared from 4-bromo-benzene-1,2-diamine and 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid (as prepared in Example 1, step B) according to the procedures described in Example 1, steps F and G. 1H-NMR (400 MHz, d4-MeOH) δ: 7.74 (s, 1H), 7.51 (d, J=8.6 Hz, 1H), 7.40 (dd, J=8.6, 1.8 Hz, 1H), 3.25 (s, 2H), 1.69-1.87 (m, 6H), 1.45-1.63 (m, 4H).

Sources & evidence

ORD record
ord-91aba59cda1847cfb93be74b4833e586
Source dataset
uspto-grants-2012_07
Patent number
US08232409B2

Reaction notes

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