2-Chlorophenylboronic acid → HCID 178478011, compound

HRID 1518159Notes

Reaction equation

HRID 1518159 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7]([C:9]3[CH2:13][C:12]4([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]4)[O:11][N:10]=3)=[N:8][C:4]=2[CH:3]=1.[Cl:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[Cl:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7]([C:9]3[CH2:13][C:12]4([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]4)[O:11][N:10]=3)=[N:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 178419324HCID 178419324, compound

Product 1

HCID 178478011HCID 178478011, compound

Procedure

The title compound was prepared from 3-(5-bromo-1H-benzimidazol-2-yl)-1-oxa-2-aza-spiro[4.5]dec-2-ene (as prepared in the previous step) and 2-chloro-benzene-boronic acid according to the procedure described in Example 1, step D. 1H-NMR (400 MHz, d4-MeOH) δ: 7.46-7.76 (m, 3H), 7.29-7.42 (m, 4H), 3.27 (s, 2H), 1.69-1.87 (m, 6H), 1.46-1.62 (m, 4H).

Sources & evidence

ORD record
ord-9ef74b1ae94d4af1a56e0fa8f2a1b833
Source dataset
uspto-grants-2012_07
Patent number
US08232409B2

Reaction notes

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