Hydrochloric Acid → N-(benzo[d]thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide dihydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1A) (8.5 g, 20.75 mmol) in DCM (80 mL) was added 2N HCl in ether (80 mL). The reaction mixture was stirred at rt overnight and concentrated under reduced pressure to provide the desired product N-(benzo[d]thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide dihydrochloride (1B): LC/MS(APCI): m/z 309.9 (M+H).

Provenance & Evidence