反应详情

To a solution of tert-butyl 8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1A) (8.5 g, 20.75 mmol) in DCM (80 mL) was added 2N HCl in ether (80 mL). The reaction mixture was stirred at rt overnight and concentrated under reduced pressure to provide the desired product N-(benzo[d]thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide dihydrochloride (1B): LC/MS(APCI): m/z 309.9 (M+H).

1. concentrationconcentrated under reduced pressure