4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 4-(4-(Isopropylamino)thieno[3,2-d]pyrimidin-7-yl)phenol

참여 물질

역할	이름	HCID	투입량
반응물	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol	HCID 2734624	—
반응물	4-(Hydroxymethyl)benzeneboronic acid	HCID 2734706	—
반응물	ethyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylate	HCID 59447480	—
반응물	7-bromo-N-isopropylthieno[3,2-d]pyrimidin-4-amine	HCID 59447642	—
생성물	4-(4-(Isopropylamino)thieno[3,2-d]pyrimidin-7-yl)phenol	HCID 59447503	—

반응 단계

The title compound 69B was prepared in a similar manner to the synthesis of compound 34D by substituting compound 34C and 4-(hydroxymethyl)phenylboronic acid with compound 69A and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 9.49 (s, 1H), 8.50 (s, 1H), 8.10 (s, 1H), 7.88-7.91 (m, 2H), 7.57 (d, J=7.67 Hz, 1H), 6.83-6.86 (m, 2H), 4.44-4.53 (m, 1H), 1.25 (d, J=6.75 Hz, 6H). ESI (+)/MS: 286 (M−H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08232273B2
출처 데이터셋	uspto-grants-2012_07
ORD ID	ord-42a9cff2b02540e7b737e9d003ddf2b9
출처 메모	uspto-grants-2012_07