反应详情

The title compound 86 was prepared as a TFA salt in a similar manner to the synthesis of compound 51 by substituting compound 51A with compound 86A: 1H NMR (DMSO-d6): δ 8.96 (d, J=2.45 Hz, 1H), 8.76 (d, J=2.45 Hz, 1H), 8.02 (d, J=7.98 Hz, 2H), 7.90-7.93 (d, J=7.98 Hz, 2H), 7.78 (d, J=7.98 Hz, 1H), 7.67 (d J=7.67 Hz, 1H), 7.33-7.49 (m, 4H), 7.11-7.15 (m, 2H), 4.84 (s, 2H), 4.1 (t, J=6.29 Hz, 2H), 3.70-3.74 (m, 2H), 3.19-3.23 (m, 2H), 3.03 (t, J=5.83 Hz, 2H), 2.02-2.09 (m, 2H). ESI (+)/MS: 674 (M+H)+.