反应详情

The title compound 87 was prepared as a TFA salt in a similar manner to the synthesis of compound 51 by substituting compound 51A with compound 87A: 1H NMR (DMSO-d6): δ 12.85 (s, 1H), 9.65 (s, 1H), 8.03 (d, J=7.67 Hz, 1H), 7.79 (d, J=7.98 Hz, 2H), 7.67 (d, J=7.67 Hz, 1H), 7.34-7.50 (m, 4H), 7.12 (t, J=8.13 Hz, 1H), 6.54 (dd, J=8.13, 2.3 Hz, 1H), 6.50 (t, J=2.15 Hz, 1H), 6.42 (dd, J=8.29, 2.15 Hz, 1H), 4.83 (s, 2H), 3.96 (t, J=6.29 Hz, 2H), 3.73 (t, J=5.83 Hz, 2H), 3.10-3.18 (m, 5H), 3.03 (t, J=5.98 Hz, 2H), 2.90-2.98 (m, 2H), 2.85 (s, 3H), 1.95-2.02 (m, 2H). ESI (+)/MS: 669 M+H)+.