4-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholine → 4-[2-(Morpholin-4-yl)ethoxy]phenol

HRID 1518375Notes

Reaction equation

HRID 1518375 reaction equation
NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(O)=CC=2)C=1C#N.C([O:30][C:31]1[CH:45]=[CH:44][C:34]([O:35][CH2:36][CH2:37][N:38]2[CH2:43][CH2:42][O:41][CH2:40][CH2:39]2)=[CH:33][CH:32]=1)C1C=CC=CC=1>>[O:41]1[CH2:40][CH2:39][N:38]([CH2:37][CH2:36][O:35][C:34]2[CH:44]=[CH:45][C:31]([OH:30])=[CH:32][CH:33]=2)[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 22969504-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholineHCID 136027725tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate

Product 1

HCID 231324384-[2-(Morpholin-4-yl)ethoxy]phenol

Procedure

Compound 88B was prepared in a similar manner to the synthesis of compound 31F by substituting compound 31E with compound 88A: 1H NMR (DMSO-d6): δ 8.84 (s, 1H), 6.72-6.75 (m, 2H), 6.64-6.67 (m, 2H), 3.96 (d, J=5.83 Hz, 2H), 3.55-3.58 (m 4H), 2.63 (d, J=5.83 Hz, 2H), 2.42-2.46 (m, 4H). ESI (+)/MS: 224 (M+H)+.

Sources & evidence

ORD record
ord-1d2e8a466de64c0e9c98989a2d073b88
Source dataset
uspto-grants-2012_07
Patent number
US08232273B2

Reaction notes

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