4-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholine → 4-[2-(Morpholin-4-yl)ethoxy]phenol

Participants

Role	Name	HCID	Charge
Reactant	4-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholine	HCID 2296950	—
Reactant	tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate	HCID 136027725	—
Product	4-[2-(Morpholin-4-yl)ethoxy]phenol	HCID 23132438	—

Reaction Steps

Compound 88B was prepared in a similar manner to the synthesis of compound 31F by substituting compound 31E with compound 88A: 1H NMR (DMSO-d6): δ 8.84 (s, 1H), 6.72-6.75 (m, 2H), 6.64-6.67 (m, 2H), 3.96 (d, J=5.83 Hz, 2H), 3.55-3.58 (m 4H), 2.63 (d, J=5.83 Hz, 2H), 2.42-2.46 (m, 4H). ESI (+)/MS: 224 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08232273B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-1d2e8a466de64c0e9c98989a2d073b88
Source note	uspto-grants-2012_07