反应详情

To a mixture of compound 110B (57 mg, 0.34 mmol), 3-morpholinopropan-1-ol (98 mg, 0.68 mmol) and triphenylphosphine (133 mg, 0.508 mmol) in THF (1.5 ml) was added (E)-di-tert-butyl diazene-1,2-dicarboxylate (117 mg, 0.508 mmol). The reaction mixture was stirred for 1 h and insoluble material was filtered off The filtrate was concentrated and the residue was purified by reverse phase HPLC (gradient: 0-55% acetonitrile in 0.1% TFA water/40 min) to provide compound 110C: LCMS (APCI) 296 (M+H).

1. filtrationinsoluble material was filtered off The filtrate
2. concentrationwas concentrated
3. customthe residue was purified by reverse phase HPLC (gradient: 0-55% acetonitrile in 0.1% TFA water/40 min)