Trifluoroacetic acid → 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)propyl)thiazole-4-carboxylic acid
Reaction equation
C(O)(C(F)(F)F)=O.[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[C:24]2[C:29]=1[CH2:28][N:27]([C:30]1[S:31][C:32]([CH2:38][CH2:39][CH2:40][O:41][C:42]3[CH:47]=[CH:46][C:45](C4C(C#N)=CSC=4)=[CH:44][CH:43]=3)=[C:33]([C:35]([OH:37])=[O:36])[N:34]=1)[CH2:26][CH2:25]2)=[O:19].[N:55]1([CH2:60][CH2:61][O:62]C2C=CC(O)=CC=2)[CH2:59][CH2:58][CH2:57][CH2:56]1>>[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[C:24]2[C:29]=1[CH2:28][N:27]([C:30]1[S:31][C:32]([CH2:38][CH2:39][CH2:40][O:41][C:42]3[CH:47]=[CH:46][C:45]([O:62][CH2:61][CH2:60][N:55]4[CH2:59][CH2:58][CH2:57][CH2:56]4)=[CH:44][CH:43]=3)=[C:33]([C:35]([OH:37])=[O:36])[N:34]=1)[CH2:26][CH2:25]2)=[O:19]Participants
4
Reactant 3
Product 1
Procedure
The title compound 114 was prepared as a TFA salt in a similar manner to the synthesis of compound 51 by substituting compound 51A with compound 106B: 1H NMR (DMSO-d6): δ 12.90 (s, 1H), 9.75 (s, 1H), 8.04 (d, J=7.93 Hz, 1H), 7.80 (d, J=7.93 Hz, 1H), 7.68 (d, J=7.32 Hz, 2H), 7.35-7.50 (m, 4H), 6.86-6.93 (m, 4H), 4.83 (s, 2H), 4.19-4.21 (m, 2H), 3.92 (d, J=6.26 Hz, 2H), 3.72 (d, J=5.95 Hz, 1H), 3.55 (br, 4H), 3.10-3.18 (m, 4H), 3.03 (t, J=5.8 Hz, 2H), 1.85-2.02 (m, 6H). ESI (+)/MS: 684 (M+H)+.
Sources & evidence
- ORD record
- ord-a7731b88d3d04818acb82bc3d9a36fdf
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08232273B2
Reaction notes
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