反应详情

温度

0 °C

To a stirred solution of compound 1G (1.9 g, 15.1 mmol) in CH2Cl2 (10 mL) at 0° C. under nitrogen were added Et3N (3.1 mL, 22.2 mmol) and benzoyl chloride (2.33 g, 16.6 mmol). The reaction was stirred at 0° C. for 60 min and RT for 30 min, then quenched with water. The product was extracted with CH2Cl2, the organics were washed with saturated aqueous NaHCO3, dried over Na2SO4, and concentrated. Purification by silica gel chromatography (5% EtOAc in hexanes) provide the title compound (3 g).

1. customquenched with water
2. extractionThe product was extracted with CH2Cl2
3. washthe organics were washed with saturated aqueous NaHCO3
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customPurification by silica gel chromatography (5% EtOAc in hexanes)