反应详情

8-Quinolinol (351 g, 2.42 mol) was dissolved in dichloromethane (3.5 L) and, under ice-water cooling, meta-chloroperbenzoic acid (675.3 g, 2.74 mol) was added thereto in portions, and the mixture was stirred at room temperature for 2 hours. Insoluble matter was removed by filtration and was washed with dichloromethane. The filtrate and the washing were mixed and concentrated under reduced pressure. To the residue, 2% aqueous ammonia (2.1 L) was added and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, and dried under reduced pressure to obtain 8-hydroxyquinoline-N-oxide (318.4 g).

1. customInsoluble matter was removed by filtration
2. washwas washed with dichloromethane
3. additionThe filtrate and the washing were mixed
4. concentrationconcentrated under reduced pressure
5. additionTo the residue, 2% aqueous ammonia (2.1 L) was added
6. stirringthe mixture was stirred at room temperature overnight
7. filtrationThe precipitate was collected by filtration
8. washwashed with purified water
9. customdried under reduced pressure